Pat - if memory services, I think Pam and Tom also used santiago adventures pre-ICE and had a very good experience. Another large travel agency down there is Cocha Travel. We used them for booking intra-Chile air, but they also offer tours and hotel bookings.
It's well worth checking the hotel price through the local agents. Same thing in Istanbul. We used the Fine Hotel & Resorts Amex program for a better rate than offered online.
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