they offered an evening tour the night we docked that took us on a tram tour around Lisbon. We found that helpful in getting a quick overview. The next morning we took the suburban train to Sintra. If you're leaving at 2 that might be cutting it close.
I think the ship was docked about 20 minutes outside of the central part of town. It is on one of the subway lines (didn't take it so not sure where it went) and it's probably a 5-10 minute walk from the ship to the closest subway/commuter train line. The ship ran free shuttles to the central square about every 1/2 hour.
Hope that helps. cheers, Anne